Older Women are being Significantly Shortchanged by Medical Research
Older Women are being Significantly Shortchanged by Medical Research
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“This has got to stop: The FDA has to require that clinical trial data be reported by sex and age for us to tell if drugs work the same, better or not as well in women,” she added. In case you loved this information and you wish to receive more information concerning naked german mature huge tits kindly visit our own site.
Consider the Alzheimer’s drug Leqembi, approved by the Food and Drug Administration last year after the manufacturer reported a 27 percent slower rate of cognitive decline in people who took the medication. A supplementary appendix to a Leqembi study published in the New England Journal of Medicine revealed that sex differences were substantial - a 12 percent slowdown for women, compared with a 43 percent slowdown for men - raising questions about the drug’s effectiveness for women.
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This is especially important because nearly two-thirds of older adults with Alzheimer’s disease are women. Older women are also more likely than older men to have multiple medical conditions, disabilities, autoimmune illnesses, depression and anxiety, uncontrolled high blood pressure and osteoarthritis, among other issues, according to scores of research studies.
Even so, women are resilient and outlive men by more than five years in the United States. If we’re concerned about the health of the older population, we need to be concerned about the health of older women. As people move into their 70s and 80s, women outnumber men by significant margins.
“We’re notably less aggressive in treating women,” said Martha Gulati, director of preventive cardiology and associate director of the Barbra Streisand Women’s Heart Center at Cedars-Sinai in Los Angeles. We’re not adequately addressing hypertension. We don’t do procedures like aortic valve replacements as often. We don’t give blood thinners at the same rate. “We delay evaluations for chest pain.
Gulati also noted that older women are less likely than their male peers to have obstructive coronary artery disease - blockages in large blood vessels - and more likely to have damage to smaller blood vessels that remains undetected. When they get procedures such as cardiac catheterizations, women have more bleeding and complications.
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“This is an area where we really need to have clear messages for women and effective interventions that are feasible and accessible,” said JoAnn Manson, chief of the Division of Preventive Medicine at Brigham and Women’s Hospital in Boston and a key researcher for the Women’s Health Initiative, the largest study of women’s health in the United States.
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Numerous factors affect women’s brain health, including stress - dealing with sexism, caregiving responsibilities and financial strain - which can fuel inflammation. They also have a higher incidence of conditions with serious impacts on the brain, such as multiple sclerosis and stroke. Women experience the loss of estrogen, a hormone important to brain health, with menopause.
The place To start out With Older Women?
Studies suggest a variety of factors, including hormonal changes and the cumulative impact of stress. In the journal Nature Aging, Paula Rochon, a professor of geriatrics at the University of Toronto, also faults “gendered ageism,” an unfortunate combination of ageism and sexism that renders older women “largely invisible.”
Helen Lavretsky, a professor of psychiatry at the University of California at Los Angeles and past president of the American Association for Geriatric Psychiatry, suggests several topics that need further investigation. (Think yoga, meditation, music therapy, tai chi, sleep therapy and other possibilities.) What combination of interventions is likely to be most effective? How does the menopausal transition impact mood and stress-related disorders? What nonpharmaceutical interventions can promote psychological resilience in older women and help them recover from stress and trauma?
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Recently, the U. S. Preventive Services Task Force noted that “the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 years or older,” leaving physicians without clear guidance. “Right now, I think we’re underscreening fit older women and overscreening frail older women,” Mohile said.
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She also wants more research about effective and safe treatments for lung cancer in older women, many of whom have multiple medical conditions and functional impairments.
Bone health, functional health and frailty
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Jane Cauley, a distinguished professor at the University of Pittsburgh School of Public Health who studies bone health, would like to see more data about osteoporosis among older Black, Asian and Hispanic women, who are undertreated for the condition. She would also like to see better drugs with fewer side effects.
Marcia Stefanick, a professor of medicine at Stanford University School of Medicine, wants to know which strategies are most likely to motivate older women to be physically active. And she’d like more studies investigating how older women can best preserve muscle mass, strength and the ability to care for themselves.